David Dowdy, MD, PhD, ScM

Faculty

Titles:

Associate Professor, Epidemiology

Joint appointments in International Health, General Internal Medicine

Physician with Johns Hopkins Community Physicians

Email:

ddowdy1@jhmi.edu

SciVal:

SciVal Link

I am a junior investigator in the field of infectious disease epidemiology, and also a practicing general internist.  My interdisciplinary research lies at the nexus of infectious disease modeling, health economics, operational and implementation science, and classical epidemiology.  My primary interests are:

(1) Modeling of TB and TB/HIV: My greatest research passion is evaluating the implementation and scale-up of TB and HIV control interventions, especially diagnostic and case-finding strategies.  I combine methods from traditional epidemiology, cost-effectiveness analysis, and epidemic modeling with the aim of answering questions of relevance to patients and policy-makers.  I serve on the steering committee of the Gates Foundation-funded TB-Modeling and Analysis Consortium (TB-MAC) and direct two NIH-funded projects related to modeling the scale-up of TB diagnostic tests.  I currently work with collaborators on projects based in Malawi, South Africa, Uganda, India, Bangladesh, Brazil, Canada, and the United States. 

(2) Translational epidemiology: I have great interest in creating modeling frameworks that allow decision-makers to translate epidemiological data into effective decisions.  I welcome collaboration from researchers, clinicians, or students having expertise in any field, who hope to create models to translate epidemiological data into meaningful policy, practical, or clinical decisions.

(3) Clinical epidemiology and patient-important outcomes: I am interested in evaluating outcomes of relevance to patients, including quality and duration of life.  Specifically, I work with a cohort study of ICU survivors in Baltimore to investigate long-term outcomes, including strength and quality of life, after critical illness.  I feel strongly about creating closer ties between the worlds of clinical practice and epidemiology.

(4) Teaching and mentorship:  These are essential, and often-undervalued, skills in the field of epidemiology.  If our profession is to continue its record of success, I firmly believe that we need to train future leaders how to teach and mentor others, and also to do our best to serve as role models in that regard.

  1. C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS ) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings.; PLoS One
  2. Costs and Consequences of Using Interferon-γ Release Assays for the Diagnosis of Active Tuberculosis ; PubMed - NCBI
  3. Reducing relapse in tuberculosis treatment: is it time to reassess WHO treatment guidelines? ; The International Journal of Tuberculosis and Lung Disease, Volume 19, Number 6, 1 June 2015, pp. 624-624(1)
  4. Performance of a Novel Algorithm Using Automated Digital Microscopy for Diagnosing Tuberculosis. ; Am J Respir Crit Care Med, ATS Journals
  5. Screening for tuberculosis with Xpert MTB/RIF versus fluorescent microscopy among adults newly diagnosed with HIV in rural Malawi: a cluster randomized trial (CHEPETSA); Clin Infect Dis
  6. Tuberculosis Incidence Among Populations at High Risk in California, Florida, New York, and Texas, 2011-2015; Am J Public Health
  7. What if they don’t have tuberculosis? The consequences and trade-offs involved in false-positive diagnoses of tuberculosis; Clin Infect Dis
  8. Post-2015 tuberculosis strategies in a pre-2015 world. ; The International Journal of Tuberculosis and Lung Disease, Volume 17, Number 2, 1 February 2013, pp. 143-143(1)
  9. Projected population-wide impact of antiretroviral therapy-linked isoniazid preventive therapy in a high-burden setting; AIDS
  10. Cost-effectiveness of Preventive Therapy for Tuberculosis With Isoniazid and Rifapentine Versus Isoniazid Alone in High-Burden Settings; Clin Infect Dis
  11. The Importance of Heterogeneity to the Epidemiology of Tuberculosis ; Clin Infect Dis
  12. Yield of household contact tracing for tuberculosis in rural South Africa ; BMC Infect Dis
  13. Modelling the impact of social protection on tuberculosis: the S-PROTECT project ; BMC Public Health
  14. Would pan-tuberculosis treatment regimens be cost-effective? ; Lancet Respir Med

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Projects

Quantitative assessment of the tipping point...

Quantitative methods will be used to study Mtb dynamics to determine the tipping point for macrophage infection, which depends...

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Assessing the social value of novel regimens...

We are collaborating with investigators from the Berman Bioethics Institute to develop novel techniques for economic evaluation...

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TB Modeling and Analysis Consortium (TB MAC)

Dr. Dowdy serves on the steering committee of an international consortium of TB modelers that aims to improve approaches to TB...

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Understanding the role of repeat testing and...

We have developed a Markov model of serial IGRA testing to help improve testing algorithms with TST vs. IGRA in low-risk...

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