Gyanu Lamichhane, PhD

Faculty

Titles:

Associate Professor, Department of Medicine, Graduate Program in Pathobiology, Graduate Program in Cellular & Molecular Medicine.

SciVal:

SciVal Link

I am a scientist with an interest in understanding fundamental mechanisms used by Mycobacterium tuberculosis to survive, grow and cause disease. Although our lab uses genetic and biochemical approaches to study this organism, we pursue questions irrespective of the expertise required to answer those questions. This means we will learn approaches/techniques that may be outside of our technical comfort zone. My laboratory undertakes basic science studies and simultaneously seeks to translate them for use in clinic.

The two major questions we are pursuing are: What are the essential components of the peptidoglycan layer and how is the physiology of this layer maintained? Please note that the peptidoglycan layer is an essential ‘organelle’. In 2007, we accidentally identified a transpeptidase that generates mDAP-mDAP or 3→3 transpeptide linkages in the peptidoglycan layer of M. tuberculosis. We are now seeking to comprehensively understand the biology of the peptidoglycan layer. The ultimate aim is to find effective ways to destroy or inhibit biosynthesis of this layer. What non-coding RNAs exist in M. tuberculosis and what is their relevance to physiology and virulence of this pathogen? In addition to rRNAs, tRNAs and tmRNA, M. tuberculosis generates a number of other non-coding RNAs. We study these RNAs.

Lamichhane Lab 

Lamichhane TB Blog

Categories

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Projects

TBM-KIDS (India)

A phase 2 clinical trial of optimized treatment for pediatric tuberculous meningitis in India and Malawi

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Comparative implementation and...

We are conducting a randomized comparative implementation trial across 56 sites in rural South Africa to evaluate three...

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Modeling the impact of novel TB drug regimens...

We are constructing mathematical models of TB epidemics in Southeast Asia, India, and Vietnam to explore the potential...

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Modeling the impact of spatially targeted TB...

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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Modeling the impact of spatially targeted TB...

We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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