Gyanu Lamichhane, PhD

Faculty

Titles:

Associate Professor, Department of Medicine, Graduate Program in Pathobiology, Graduate Program in Cellular & Molecular Medicine.

SciVal:

SciVal Link

I am a scientist with an interest in understanding fundamental mechanisms used by Mycobacterium tuberculosis to survive, grow and cause disease. Although our lab uses genetic and biochemical approaches to study this organism, we pursue questions irrespective of the expertise required to answer those questions. This means we will learn approaches/techniques that may be outside of our technical comfort zone. My laboratory undertakes basic science studies and simultaneously seeks to translate them for use in clinic.

The two major questions we are pursuing are: What are the essential components of the peptidoglycan layer and how is the physiology of this layer maintained? Please note that the peptidoglycan layer is an essential ‘organelle’. In 2007, we accidentally identified a transpeptidase that generates mDAP-mDAP or 3→3 transpeptide linkages in the peptidoglycan layer of M. tuberculosis. We are now seeking to comprehensively understand the biology of the peptidoglycan layer. The ultimate aim is to find effective ways to destroy or inhibit biosynthesis of this layer. What non-coding RNAs exist in M. tuberculosis and what is their relevance to physiology and virulence of this pathogen? In addition to rRNAs, tRNAs and tmRNA, M. tuberculosis generates a number of other non-coding RNAs. We study these RNAs.

Lamichhane Lab 

Lamichhane TB Blog

Categories

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Projects

Population-level impact of isoniazid...

We are collaborating with a team that conducted a randomized trial of IPT in Khayelitsha, South Africa, to extend their findings...

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

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ACTG trial A5343

Phase 2 safety study of bedaquiline and delamanid for the treatment of MDR-TB in South Africa

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MDR TB treatment as prevention: modeling the...

We are using transmission modeling to evaluate the potential impact of expanding DST and access to MDR TB treatment in Vietnam,...

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