Larry Moulton, PhD

Faculty

Titles:

Professor, International Health, Biostatistics

SciVal:

SciVal Link

I am involved in several group-randomized trials; those involving vaccines are especially interesting, as they afford the opportunity to measure indirect effects of immunization. I am working on methods for the design, especially the randomization, of such trials, as well as methods of analysis of the resulting correlated data.

My involvement with HIV and TB research began in the early 1990s when I started working for the Johns Hopkins University as a statistician on HIV studies and TB trials in Haiti.  I have been the principal statistician on a number of HIV and TB related studies (including the 14,000+ mother-infant pairs in the ZVITAMBO project in Zimbabwe, the male circumcision trial in Uganda, the trial of rifapentine and extended INH prophylaxis for HIV-related TB in Soweto, and the THRio study in Brazil).

My expertise is in correlated data analysis, study design, and statistical epidemiology.  In particular, I am working on the design and analysis of cluster randomized trials, especially their randomization.  I direct the Ph.D. program in Global Disease Epidemiology and Control and the Peace Corps/Masters International Program, I am Co-Director of the Institute for Vaccine Safety, and Director of the Biostatistics and Epidemiology Methodology Core of the JHU Center For AIDS Research.

Categories

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Projects

Quantiferon gold test for detecting TB...

This is a cluster randomized trial comparing the time to known latent TB status among HIV infected patients receiving QGIT...

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ACTG trial A5343

Phase 2 safety study of bedaquiline and delamanid for the treatment of MDR-TB in South Africa

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A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for adult contacts of MDR TB patients...

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Quantitative assessment of the tipping point...

Quantitative methods will be used to study Mtb dynamics to determine the tipping point for macrophage infection, which depends...

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Comparative implementation and...

We are conducting a randomized comparative implementation trial across 56 sites in rural South Africa to evaluate three...

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