Maunank Shah, MD, PhD

Faculty

Titles:

Assistant Professor in the Division of Infectious Diseases

Medical Director Baltimore City Health Department TB program

Co-Director of Microbiology/Infectious Disease block for Johns Hopkins Medical School Genes to Society curriculum

SciVal:

SciVal Link

I am a clinical investigator with a focus on HIV and TB, and also an infectious disease attending clinician.  My multi-disciplinary research focuses on the evaluation of new HIV and TB diagnostic strategies in resource limited settings, infectious disease modeling, and health economics. My primary interests are:

(1)TB diagnostics:  My research projects have spanned the spectrum of TB diagnostics research, including performing studies of diagnostic test accuracy of emerging diagnostics, evaluating programmatic impact of implementing emerging diagnostics, to determining cost-effectiveness of new TB diagnostic algorithms.  Platforms I have studied include IGRAs, Xpert MTB/RIF, Urine LAM-ELISA, and lateral-flow urine LAM assays.  I am an active member of the JHSPH TB modeling group (modeltb.org), and the Clinical Diagnostics Research Consortium. 

(2)HIV transmission: I have an interest in evaluating interventions to reduce or prevent HIV transmission. Prior projects have evaluated the cost-effectiveness of WHO recommendations for prevention of mother to child HIV transmission.  My current focus is on construction of mathematical models to explore the impact of the HIV 'treatment cascade' on population level HIV associated costs, incidence, prevalence, and death

(3)mHealth interventions:  Working with the eMocha team at the Hopkins CCGHE, we have developed an innovative platform to allow video-based Directly Observed Therapy of TB treatment.  This platform allows Health Departments to perform D.O.T. in difficult to treat patients or marginalized groups in whom in-person DOT is not logistically feasible or affordable.  There are ongoing plans for pilot studies in a variety of settings domestically and internationally.

(4)Teaching and mentorship:  I have a strong interest in teaching, and co-direct the microbiology section for the Johns Hopkins Medical School curriculum.  I serve as faculty advisor for the Bienestar Baltimore student volunteer TB outreach program, and as the research mentor for a number of nursing, public health, and medical students.  Through a collaboration with the Johns Hopkins Center for Global Health Education and the UCLA Olive View TB Unit, I host a monthly teaching forum focused on the clinical management of complex TB and MDR-TB cases (http://main.ccghe.net/content/tuberculosis-case-conference) during which we discuss clinical issues and dilemmas in the care of TB patients. 

(5)Domestic TB:  As medical director for the Baltimore City Health Dept TB program, I am keenly interested in mechanisms to reduce TB incidence and prevalence locally.  We conduct epidemiologic studies to understand the changing face of TB in the US, and have evaluated teh cost-effectiveness of new strategies for diagnosis of both latent and active TB.  

Categories

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Projects

TBM-KIDS (Malawi)

A phase 2 clinical trial of optimized treatment for pediatric tuberculous meningitis in India and Malawi

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Statins as adjunctive host-directed therapy...

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In...

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A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for adult contacts of MDR TB patients...

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Scale-up and implementation of TB diagnostics...

We are evaluating the implementation, cost-effectiveness, and potential epidemiological impact of scaling up Xpert across 19...

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Modeling the impact of spatially targeted TB...

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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