Nicole C. Ammerman, PhD, ScM

Staff

Titles:

Research Associate, Medicine, Infectious Disease, TB Center

Email:

nicole.ammerman@jhu.edu

Phone:

410-292-2957

SciVal:

SciVal Link

The fundamental basis of my work is to use science to advance the global control of tuberculosis and limit the suffering of people with tuberculosis and nontuberculous mycobacterial diseases. Specifically, my research efforts are focused on improving the treatment of these diseases by using in vitro and in vivo experimental chemotherapy models to evaluate the antimycobacterial activity of compounds, drugs, and regimens; and to study drug, host, and pathogen factors that influence treatment outcome. My research is translational; the ultimate goal of all my work is to provide reliable preclinical data that can be used to inform drug and regimen development and clinical trial design. Current research projects include investigation of the treatment-shortening potential of clofazimine in regimens for drug-susceptible tuberculosis; evaluation of a long-acting injectable formulation of bedaquiline for tuberculosis preventive therapy; and development of nontuberculous mycobacteria infection models for treatment studies.

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Projects

Decentralized testing for tuberculosis with...

This is a highly pragmatic cluster randomized trial to compare the impact, implementation, and cost-effectiveness of on-site...

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TB Modeling and Analysis Consortium (TB MAC)

Dr. Dowdy serves on the steering committee of an international consortium of TB modelers that aims to improve approaches to TB...

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A novel “shock and kill” strategy...

The objective of this study is to determine if pharmacological inhibition of the Mtb stringent response leads to accelerated...

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MDR TB treatment as prevention: modeling the...

We are using transmission modeling to evaluate the potential impact of expanding DST and access to MDR TB treatment in Vietnam,...

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Human-centered Design and Communities of...

The goal of this project is to use local communities of practice and the emerging technique of human-centered design to improve...

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