Nicole C. Ammerman, PhD, ScM

Staff

Titles:

Research Associate, Medicine, Infectious Disease, TB Center

Email:

nicole.ammerman@jhu.edu

Phone:

410-292-2957

SciVal:

SciVal Link

The fundamental basis of my work is to use science to advance the global control of tuberculosis and limit the suffering of people with tuberculosis and nontuberculous mycobacterial diseases. Specifically, my research efforts are focused on improving the treatment of these diseases by using in vitro and in vivo experimental chemotherapy models to evaluate the antimycobacterial activity of compounds, drugs, and regimens; and to study drug, host, and pathogen factors that influence treatment outcome. My research is translational; the ultimate goal of all my work is to provide reliable preclinical data that can be used to inform drug and regimen development and clinical trial design. Current research projects include investigation of the treatment-shortening potential of clofazimine in regimens for drug-susceptible tuberculosis; evaluation of a long-acting injectable formulation of bedaquiline for tuberculosis preventive therapy; and development of nontuberculous mycobacteria infection models for treatment studies.

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Projects

A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for pediatric contacts of MDR TB...

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Statins as Adjunctive, Host-Directed Therapy...

The goal of this study is to investigate the potential utility of pravastatin as an adjunctive, host-directed therapy for...

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Understanding the role of repeat testing and...

We have developed a Markov model of serial IGRA testing to help improve testing algorithms with TST vs. IGRA in low-risk...

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Statins as adjunctive host-directed therapy...

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In...

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