Paul Converse, PhD

Titles:

Research Analyst, Hopkins Medicine

SciVal:

SciVal Link

My research interests concern the pathogens, Mycobacterium tuberculosis and M. ulcerans, in humans and experimental animal hosts. Studies in tuberculosis, principally in the mouse model, concern the response to chemotherapeutic agents, including novel compounds and novel combinations of drugs, and their modulation due to innate host factors and those involving the immune system after immunotherapeutic vaccination. Studies on M. ulcerans, the causative agent of Buruli ulcer, have focused on the differential response to vaccination in different mouse strains and the evaluation of novel chemotherapy regimens in comparison with the WHO standard of rifampin and streptomycin. We are also involved in studies to develop appropriate assays to detect mycolactone, the toxin that is the principal virulence factor of M. ulcerans.

Categories

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Projects

TBM-KIDS (India)

A phase 2 clinical trial of optimized treatment for pediatric tuberculous meningitis in India and Malawi

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Scale-up and implementation of TB diagnostics...

We are evaluating the implementation, cost-effectiveness, and potential epidemiological impact of scaling up Xpert across 19...

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Modeling the impact of spatially targeted TB...

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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Understanding the role of repeat testing and...

We have developed a Markov model of serial IGRA testing to help improve testing algorithms with TST vs. IGRA in low-risk...

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Modeling the impact of novel TB drug regimens...

We are constructing mathematical models of TB epidemics in Southeast Asia, India, and Vietnam to explore the potential...

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