Paul Converse, PhD

Titles:

Research Analyst, Hopkins Medicine

SciVal:

SciVal Link

My research interests concern the pathogens, Mycobacterium tuberculosis and M. ulcerans, in humans and experimental animal hosts. Studies in tuberculosis, principally in the mouse model, concern the response to chemotherapeutic agents, including novel compounds and novel combinations of drugs, and their modulation due to innate host factors and those involving the immune system after immunotherapeutic vaccination. Studies on M. ulcerans, the causative agent of Buruli ulcer, have focused on the differential response to vaccination in different mouse strains and the evaluation of novel chemotherapy regimens in comparison with the WHO standard of rifampin and streptomycin. We are also involved in studies to develop appropriate assays to detect mycolactone, the toxin that is the principal virulence factor of M. ulcerans.

Categories

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Projects

A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for pediatric contacts of MDR TB...

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

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ACTG trial A5343

Phase 2 safety study of bedaquiline and delamanid for the treatment of MDR-TB in South Africa

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APT: Assessing PA-824 for Tuberculosis

A Phase 2 clinical trial of PA-824, an investigational nitroimidazole, as part of multidrug therapy for pulmonary TB; in...

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Understanding the impact of combined TB and...

We are developing models to understand the overlap of TB and HIV in three epidemiologically distinct settings (Canada, India,...

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