Comparative Effectiveness/Implementation of TB Case Finding in Rural South Africa: The Kharitode

Dates

01/15/2015 - 12/13/2019

PI

David Dowdy, MD, PhD

This cluster-randomized trial in 56 rural primary care clinics compares the effectiveness and implementation of three strategies for active tuberculosis case finding: household contact tracing, incentive-based contact tracing, and facility-

  based screening. We aim to demonstrate which of these strategies finds the most cases and does so in the most cost-effective fashion.

Projects

mHealth for improved TB contact investigation...

This multicenter randomized study is evaluating the implementation, effectiveness, cost-effectiveness, and population-level...

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A smoking cessation trial in HIV/AIDS...

A tobacco prevalence survey and smoking cessation trial among HIV infected patients in South Africa.

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Statins as Adjunctive, Host-Directed Therapy...

The goal of this study is to investigate the potential utility of pravastatin as an adjunctive, host-directed therapy for...

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A novel “shock and kill” strategy...

The objective of this study is to determine if pharmacological inhibition of the Mtb stringent response leads to accelerated...

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Assessing the social value of novel regimens...

We are collaborating with investigators from the Berman Bioethics Institute to develop novel techniques for economic evaluation...

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