Comparative implementation and cost-effectiveness of active TB case finding in rural South Africa

Location

Vhembe, South Africa, South Africa

Dates

01/25/2015 - 12/01/2019

PI

David Dowdy, MD, PhD, ScM

We are conducting a randomized comparative implementation trial across 56 sites in rural South Africa to evaluate three strategies for active case finding: facility-based screening, household contact tracing, and incentive-based contact tracing.

Projects

Assessing the social value of novel regimens...

We are collaborating with investigators from the Berman Bioethics Institute to develop novel techniques for economic evaluation...

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

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Modeling the impact of spatially targeted TB...

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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Quantitative assessment of the tipping point...

Quantitative methods will be used to study Mtb dynamics to determine the tipping point for macrophage infection, which depends...

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