Decentralized testing for tuberculosis with on-site Xpert Ultra: the XPEL TB trial

Dates

01/15/2016 - 12/31/2020

PI

David Dowdy, MD, PhD, ScM

This is a highly pragmatic cluster randomized trial to compare the impact, implementation, and cost-effectiveness of on-site versus “hub-and-spoke” testing for TB using Xpert Ultra in 20 primary health centers in Uganda.

Projects

A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for pediatric contacts of MDR TB...

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Understanding the role of repeat testing and...

We have developed a Markov model of serial IGRA testing to help improve testing algorithms with TST vs. IGRA in low-risk...

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Assessing the social value of novel regimens...

We are collaborating with investigators from the Berman Bioethics Institute to develop novel techniques for economic evaluation...

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Immunotherapy Targeting MTB Persisters in the...

The goal of this research program is to determine whether enhanced immunity to critical components of the Mtb stringent response...

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