Decentralized testing for tuberculosis with on-site Xpert Ultra: the XPEL TB trial

Dates

01/15/2016 - 12/31/2020

PI

David Dowdy, MD, PhD

This is a highly pragmatic cluster randomized trial to compare the impact, implementation, and cost-effectiveness of on-site versus “hub-and-spoke” testing for TB using Xpert Ultra in 20 primary health centers in Uganda.

Projects

TB Modeling and Analysis Consortium (TB MAC)

Dr. Dowdy serves on the steering committee of an international consortium of TB modelers that aims to improve approaches to TB...

Read More

A novel “shock and kill” strategy...

The objective of this study is to determine if pharmacological inhibition of the Mtb stringent response leads to accelerated...

Read More

Quantitative assessment of the tipping point...

Quantitative methods will be used to study Mtb dynamics to determine the tipping point for macrophage infection, which depends...

Read More