FlexDx-TB: A flexible, user-friendly model of TB diagnostics

Location

Baltimore, Maryland, US

Dates

07/01/2012 - 06/01/2015

PI

David Dowdy, MD, PhD, ScM

We have developed a web-based model that allows decision-makers to input local epidemiological and economic values and receive customized estimates of impact and cost-effectiveness related to different strategies for scaling up TB diagnostics.  We are now collaborating with colleagues at USAID to test the model for on-the-ground decisions being made in Mozambique.

Projects

APT: Assessing PA-824 for Tuberculosis

A Phase 2 clinical trial of PA-824, an investigational nitroimidazole, as part of multidrug therapy for pulmonary TB; in...

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A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for pediatric contacts of MDR TB...

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Modeling the impact of spatially targeted TB...

We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

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Comparative implementation and...

We are conducting a randomized comparative implementation trial across 56 sites in rural South Africa to evaluate three...

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