Modeling the impact of novel TB drug regimens and drug susceptibility tests

Location

Baltimore, Maryland, US

Dates

04/01/2013 - 06/01/2015

PI

David Dowdy, MD, PhD, ScM

We are constructing mathematical models of TB epidemics in Southeast Asia, India, and Vietnam to explore the potential population-level impact of drug susceptibility testing and novel TB drug regimens including PaMZ on the epidemic of MDR TB.

Projects

Statins as adjunctive host-directed therapy...

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In...

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A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for pediatric contacts of MDR TB...

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TBM-KIDS (India)

A phase 2 clinical trial of optimized treatment for pediatric tuberculous meningitis in India and Malawi

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FlexDx-TB: A flexible, user-friendly model of...

We have developed a web-based model that allows decision-makers to input local epidemiological and economic values and receive...

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Quantiferon gold test for detecting TB...

This is a cluster randomized trial comparing the time to known latent TB status among HIV infected patients receiving QGIT...

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