Modeling the impact of novel TB drug regimens and drug susceptibility tests

Location

Baltimore, Maryland, US

Dates

04/01/2013 - 06/01/2015

PI

David Dowdy, MD, PhD, ScM

We are constructing mathematical models of TB epidemics in Southeast Asia, India, and Vietnam to explore the potential population-level impact of drug susceptibility testing and novel TB drug regimens including PaMZ on the epidemic of MDR TB.

Projects

A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for adult contacts of MDR TB patients...

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FlexDx-TB: A flexible, user-friendly model of...

We have developed a web-based model that allows decision-makers to input local epidemiological and economic values and receive...

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

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TBM-KIDS (Malawi)

A phase 2 clinical trial of optimized treatment for pediatric tuberculous meningitis in India and Malawi

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Comparative implementation and...

We are conducting a randomized comparative implementation trial across 56 sites in rural South Africa to evaluate three...

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