Modeling the impact of novel TB drug regimens and drug susceptibility tests

Location

Baltimore, Maryland, US

Dates

04/01/2013 - 06/01/2015

PI

David Dowdy, MD, PhD, ScM

We are constructing mathematical models of TB epidemics in Southeast Asia, India, and Vietnam to explore the potential population-level impact of drug susceptibility testing and novel TB drug regimens including PaMZ on the epidemic of MDR TB.

Projects

Modeling the impact of spatially targeted TB...

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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TBM-KIDS (Malawi)

A phase 2 clinical trial of optimized treatment for pediatric tuberculous meningitis in India and Malawi

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FlexDx-TB: A flexible, user-friendly model of...

We have developed a web-based model that allows decision-makers to input local epidemiological and economic values and receive...

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A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for adult contacts of MDR TB patients...

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Assessing the social value of novel regimens...

We are collaborating with investigators from the Berman Bioethics Institute to develop novel techniques for economic evaluation...

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