Modeling the impact of spatially targeted TB vaccines

Location

South Africa, South Africa

Dates

01/01/2014 - 04/01/2015

PI

David Dowdy, MD, PhD, ScM

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of transmission, relative to general untargeted vaccination strategies, as a function of geographical heterogeneity and population mixing.

Projects

A novel “shock and kill” strategy...

The objective of this study is to determine if pharmacological inhibition of the Mtb stringent response leads to accelerated...

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A Comprehensive Snapshot of Tuberculosis...

This study aims to find all cases of TB within an urban Ugandan community of 50,000 people and to characterize both the...

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Decentralized testing for tuberculosis with...

This is a highly pragmatic cluster randomized trial to compare the impact, implementation, and cost-effectiveness of on-site...

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Comparative implementation and...

We are conducting a randomized comparative implementation trial across 56 sites in rural South Africa to evaluate three...

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Statins as adjunctive host-directed therapy...

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In...

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