Modeling the impact of spatially targeted TB vaccines

Location

South Africa, South Africa

Dates

01/01/2014 - 04/01/2015

PI

David Dowdy, MD, PhD, ScM

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of transmission, relative to general untargeted vaccination strategies, as a function of geographical heterogeneity and population mixing.

Projects

ACTG trial A5343

Phase 2 safety study of bedaquiline and delamanid for the treatment of MDR-TB in South Africa

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APT: Assessing PA-824 for Tuberculosis

A Phase 2 clinical trial of PA-824, an investigational nitroimidazole, as part of multidrug therapy for pulmonary TB; in...

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TBM-KIDS (Malawi)

A phase 2 clinical trial of optimized treatment for pediatric tuberculous meningitis in India and Malawi

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