Modeling the impact of spatially targeted TB vaccines

Location

South Africa, South Africa

Dates

01/01/2014 - 04/01/2015

PI

David Dowdy, MD, PhD, ScM

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of transmission, relative to general untargeted vaccination strategies, as a function of geographical heterogeneity and population mixing.

Projects

Quantitative assessment of the tipping point...

Quantitative methods will be used to study Mtb dynamics to determine the tipping point for macrophage infection, which depends...

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FlexDx-TB: A flexible, user-friendly model of...

We have developed a web-based model that allows decision-makers to input local epidemiological and economic values and receive...

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Quantiferon gold test for detecting TB...

This is a cluster randomized trial comparing the time to known latent TB status among HIV infected patients receiving QGIT...

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Understanding the role of repeat testing and...

We have developed a Markov model of serial IGRA testing to help improve testing algorithms with TST vs. IGRA in low-risk...

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Evaluating an automated system for...

We are evaluating the accuracy and cost-effectiveness of TBDx, an automated digital microscopy system, as a screening test to...

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