Modeling the impact of spatially targeted TB vaccines

Location

Gujarat, India, India

Dates

01/01/2014 - 04/01/2015

PI

David Dowdy, MD, PhD, ScM

We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of transmission, relative to general untargeted vaccination strategies, as a function of geographical heterogeneity and population mixing.

Projects

Statins as Adjunctive, Host-Directed Therapy...

The goal of this study is to investigate the potential utility of pravastatin as an adjunctive, host-directed therapy for...

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Quantitative assessment of the tipping point...

Quantitative methods will be used to study Mtb dynamics to determine the tipping point for macrophage infection, which depends...

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Modeling the impact of novel TB drug regimens...

We are constructing mathematical models of TB epidemics in Southeast Asia, India, and Vietnam to explore the potential...

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Options for Patient-Centered Delivery of...

This individually randomized trial is evaluating the relative effectiveness of self-administered therapy, directly observed...

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Understanding the costs and...

We have conducted an empirical costing analysis of facility-based versus community-based treatment for TB in Bangladesh and are...

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