Quantitative assessment of the tipping point in Mycobacterium tuberculosis transmission and

Location

Baltimore, Maryland, US

Dates

12/01/2014 - 11/30/2017

PI

Petros Karakousis, MD

Quantitative methods will be used to study Mtb dynamics to determine the tipping point for macrophage infection, which depends on the number and state of internalized bacteria and leads to either control of infection or uncontrolled Mtb replication.

Projects

TBM-KIDS (Malawi)

A phase 2 clinical trial of optimized treatment for pediatric tuberculous meningitis in India and Malawi

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

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A Blueprint for Success: Understanding the...

We are using a combination of statistical analysis and transmission modeling, in collaboration with the NYC Dept of Health &...

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