Scale-up and implementation of TB diagnostics including Xpert in Uganda

Location

Uganda, Uganda

Dates

05/25/2015 - 05/01/2016

PI

David Dowdy, MD, PhD, ScM

We are evaluating the implementation, cost-effectiveness, and potential epidemiological impact of scaling up Xpert across 19 stand-alone clinics and 2 larger referral networks across Uganda (including in Kampala).  We are also evaluating the role and cost-effectiveness of "triage" testing in peripheral clinics using CRP and other novel biomarkers.

Projects

Modeling the impact of spatially targeted TB...

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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APT: Assessing PA-824 for Tuberculosis

A Phase 2 clinical trial of PA-824, an investigational nitroimidazole, as part of multidrug therapy for pulmonary TB; in...

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A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for pediatric contacts of MDR TB...

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Understanding the impact of combined TB and...

We are developing models to understand the overlap of TB and HIV in three epidemiologically distinct settings (Canada, India,...

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