Scale-up and implementation of TB diagnostics including Xpert in Uganda

Location

Uganda, Uganda

Dates

05/25/2015 - 05/01/2016

PI

David Dowdy, MD, PhD, ScM

We are evaluating the implementation, cost-effectiveness, and potential epidemiological impact of scaling up Xpert across 19 stand-alone clinics and 2 larger referral networks across Uganda (including in Kampala).  We are also evaluating the role and cost-effectiveness of "triage" testing in peripheral clinics using CRP and other novel biomarkers.

Projects

A Comprehensive Snapshot of Tuberculosis...

This study aims to find all cases of TB within an urban Ugandan community of 50,000 people and to characterize both the...

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A novel “shock and kill” strategy...

The objective of this study is to determine if pharmacological inhibition of the Mtb stringent response leads to accelerated...

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Population-level impact of isoniazid...

We are collaborating with a team that conducted a randomized trial of IPT in Khayelitsha, South Africa, to extend their findings...

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Impact of diabetes on TB treatment outcomes...

This is a study to prospectively enroll and follow TB patients co-infected with diabetes and TB patients without diabetes...

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