Statins as adjunctive host-directed therapy for TB

Location

Johannesburg, South Africa

Dates

10/01/2017 - 09/30/2020

PI

Petros Karakousis, MD

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In addition, we will use a variety of different high-throughput techniques, including RNA-seq to investigate the mechanism of action of statins.

Projects

A Comprehensive Snapshot of Tuberculosis...

This study aims to find all cases of TB within an urban Ugandan community of 50,000 people and to characterize both the...

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Understanding the impact of combined TB and...

We are developing models to understand the overlap of TB and HIV in three epidemiologically distinct settings (Canada, India,...

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Impact of diabetes on TB treatment outcomes...

This is a study to prospectively enroll and follow TB patients co-infected with diabetes and TB patients without diabetes...

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Quantiferon gold test for detecting TB...

This is a cluster randomized trial comparing the time to known latent TB status among HIV infected patients receiving QGIT...

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