Statins as adjunctive host-directed therapy for TB

Location

Johannesburg, South Africa

Dates

10/01/2017 - 09/30/2020

PI

Petros Karakousis, MD

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In addition, we will use a variety of different high-throughput techniques, including RNA-seq to investigate the mechanism of action of statins.

Projects

Quantiferon gold test for detecting TB...

This is a cluster randomized trial comparing the time to known latent TB status among HIV infected patients receiving QGIT...

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Population-level impact of isoniazid...

We are collaborating with a team that conducted a randomized trial of IPT in Khayelitsha, South Africa, to extend their findings...

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Statins as adjunctive host-directed therapy...

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In...

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A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for pediatric contacts of MDR TB...

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Options for Patient-Centered Delivery of...

This individually randomized trial is evaluating the relative effectiveness of self-administered therapy, directly observed...

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