Statins as adjunctive host-directed therapy for TB

Location

Baltimore, Maryland, US

Dates

03/15/2015 - 03/14/2016

PI

Petros Karakousis, MD

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In addition, we will use a variety of different high-throughput techniques, including RNA-seq to investigate the mechanism of action of statins.

Projects

Population-level impact of isoniazid...

We are collaborating with a team that conducted a randomized trial of IPT in Khayelitsha, South Africa, to extend their findings...

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MDR TB treatment as prevention: modeling the...

We are using transmission modeling to evaluate the potential impact of expanding DST and access to MDR TB treatment in Vietnam,...

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Modeling to improve TB decision-making in the...

We are part of a large consortium that is constructing epidemic and economic models of TB and HIV in collaboration with the U.S....

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