Statins as adjunctive host-directed therapy for TB

Location

Baltimore, Maryland, US

Dates

03/15/2015 - 03/14/2016

PI

Petros Karakousis, MD

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In addition, we will use a variety of different high-throughput techniques, including RNA-seq to investigate the mechanism of action of statins.

Projects

Modeling the impact of spatially targeted TB...

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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Quantiferon gold test for detecting TB...

This is a cluster randomized trial comparing the time to known latent TB status among HIV infected patients receiving QGIT...

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

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