Statins as adjunctive host-directed therapy for TB

Location

Johannesburg, South Africa

Dates

10/01/2017 - 09/30/2020

PI

Petros Karakousis, MD

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In addition, we will use a variety of different high-throughput techniques, including RNA-seq to investigate the mechanism of action of statins.

Projects

Understanding the role of repeat testing and...

We have developed a Markov model of serial IGRA testing to help improve testing algorithms with TST vs. IGRA in low-risk...

Read More

Statins as adjunctive host-directed therapy...

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In...

Read More

Evaluation of a novel serum biosignature for...

This study will use multiple high-throughput modalities, including LC-MS/MS and RNA-seq, to detect a panel of host metabolites...

Read More