The role of cell wall lipids in pathogenesis of rifampin-resistant TB

Location

Baltimore, Maryland, US

Dates

08/19/2013 - 12/31/2019

PI

Petros Karakousis, MD

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether phthiocerol dimycocerosate (PDIM) accumulation compensates for the fitness cost associated with M. tuberculosis rpoB mutation during host infection.

Projects

Comparative Effectiveness/Implementation of...

This cluster-randomized trial in 56 rural primary care clinics compares the effectiveness and implementation of three strategies...

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A smoking cessation trial in HIV/AIDS...

A tobacco prevalence survey and smoking cessation trial among HIV infected patients in South Africa.

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A Nurse Case Management Intervention to...

Dr. Farley is responsible for the overall project from design, implementation, data collection, and preparation of...

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FlexDx-TB: A flexible, user-friendly model of...

We have developed a web-based model that allows decision-makers to input local epidemiological and economic values and receive...

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Immunotherapy Targeting MTB Persisters in the...

The goal of this research program is to determine whether enhanced immunity to critical components of the Mtb stringent response...

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