The role of cell wall lipids in pathogenesis of rifampin-resistant TB

Location

Baltimore, Maryland, US

Dates

08/19/2013 - 12/31/2019

PI

Petros Karakousis, MD

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether phthiocerol dimycocerosate (PDIM) accumulation compensates for the fitness cost associated with M. tuberculosis rpoB mutation during host infection.

Projects

Modeling the impact of spatially targeted TB...

We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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MDR TB treatment as prevention: modeling the...

We are using transmission modeling to evaluate the potential impact of expanding DST and access to MDR TB treatment in Vietnam,...

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A novel “shock and kill” strategy...

The objective of this study is to determine if pharmacological inhibition of the Mtb stringent response leads to accelerated...

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Modeling the impact of novel TB drug regimens...

We are constructing mathematical models of TB epidemics in Southeast Asia, India, and Vietnam to explore the potential...

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A Comprehensive Snapshot of Tuberculosis...

This study aims to find all cases of TB within an urban Ugandan community of 50,000 people and to characterize both the...

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