The role of cell wall lipids in pathogenesis of rifampin-resistant TB

Location

Baltimore, Maryland, US

Dates

08/19/2013 - 07/31/2016

PI

Petros Karakousis, MD

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether phthiocerol dimycocerosate (PDIM) accumulation compensates for the fitness cost associated with M. tuberculosis rpoB mutation during host infection.

Projects

A Nurse Case Management Intervention to...

Dr. Farley is responsible for the overall project from design, implementation, data collection, and preparation of...

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ACTG trial A5343

Phase 2 safety study of bedaquiline and delamanid for the treatment of MDR-TB in South Africa

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TBM-KIDS (Malawi)

A phase 2 clinical trial of optimized treatment for pediatric tuberculous meningitis in India and Malawi

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Scale-up and implementation of TB diagnostics...

We are evaluating the implementation, cost-effectiveness, and potential epidemiological impact of scaling up Xpert across 19...

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