The role of cell wall lipids in pathogenesis of rifampin-resistant TB

Location

Baltimore, Maryland, US

Dates

08/19/2013 - 07/31/2016

PI

Petros Karakousis, MD

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether phthiocerol dimycocerosate (PDIM) accumulation compensates for the fitness cost associated with M. tuberculosis rpoB mutation during host infection.

Projects

Modeling the impact of spatially targeted TB...

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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Scale-up and implementation of TB diagnostics...

We are evaluating the implementation, cost-effectiveness, and potential epidemiological impact of scaling up Xpert across 19...

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ICOHRTA Training Program (Fogarty)

International Clinical, Operational, and Health Services Research Award (ICOHRTA) training program. A training program that...

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

Read More