Understanding the impact of combined TB and HIV diagnosis in diverse epidemics

Location

Canada, Canada

Dates

10/01/2012 - 03/01/2016

PI

David Dowdy, MD, PhD, ScM

We are developing models to understand the overlap of TB and HIV in three epidemiologically distinct settings (Canada, India, and Uganda), including the potential role of different combined diagnostic strategies, given the different breakdown of populations at high TB risk, high HIV risk, and high combined TB/HIV risk.

Projects

A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for pediatric contacts of MDR TB...

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Scale-up and implementation of TB diagnostics...

We are evaluating the implementation, cost-effectiveness, and potential epidemiological impact of scaling up Xpert across 19...

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Modeling the impact of spatially targeted TB...

 We have developed transmission models to understand the impact of TB vaccination strategies that target hotspots of...

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Statins as Adjunctive, Host-Directed Therapy...

The goal of this study is to investigate the potential utility of pravastatin as an adjunctive, host-directed therapy for...

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

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