Understanding the impact of combined TB and HIV diagnosis in diverse epidemics

Location

Canada, Canada

Dates

10/01/2012 - 03/01/2016

PI

David Dowdy, MD, PhD, ScM

We are developing models to understand the overlap of TB and HIV in three epidemiologically distinct settings (Canada, India, and Uganda), including the potential role of different combined diagnostic strategies, given the different breakdown of populations at high TB risk, high HIV risk, and high combined TB/HIV risk.

Projects

Immunotherapy Targeting MTB Persisters in the...

The goal of this research program is to determine whether enhanced immunity to critical components of the Mtb stringent response...

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ACTG trial A5343

Phase 2 safety study of bedaquiline and delamanid for the treatment of MDR-TB in South Africa

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Statins as adjunctive host-directed therapy...

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In...

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Understanding the costs and...

We have conducted an empirical costing analysis of facility-based versus community-based treatment for TB in Bangladesh and are...

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mHealth for improved TB contact investigation...

This multicenter randomized study is evaluating the implementation, effectiveness, cost-effectiveness, and population-level...

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