Metformin adjunctive therapy does not improve the sterilizing activity of the first-line antitubercular regimen in mice

Published Date:

11/30/2018

Source:

Antimicrob Agents Chemother

Authors:

Dutta NK, Pinn ML, Karakousis PC

External link

Original Article

Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of tuberculosis (TB). In this study, we sought to investigate the bactericidal and sterilizing activities of human-like exposures of metformin when given in combination with the first-line regimen against chronic tuberculosis in BALB/c mice. Mice receiving metformin adjunctive therapy had similar lung bacillary burdens with control mice during treatment, and the proportion of mice with microbiological relapse was similar between the two groups.

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