Nicole C. Ammerman, PhD, ScM

Staff

Titles:

Research Associate, Medicine, Infectious Disease, TB Center

Email:

nicole.ammerman@jhu.edu

Phone:

410-292-2957

SciVal:

SciVal Link

The fundamental basis of my work is to use science to advance the global control of tuberculosis and limit the suffering of people with tuberculosis and nontuberculous mycobacterial diseases. Specifically, my research efforts are focused on improving the treatment of these diseases by using in vitro and in vivo experimental chemotherapy models to evaluate the antimycobacterial activity of compounds, drugs, and regimens; and to study drug, host, and pathogen factors that influence treatment outcome. My research is translational; the ultimate goal of all my work is to provide reliable preclinical data that can be used to inform drug and regimen development and clinical trial design. Current research projects include investigation of the treatment-shortening potential of clofazimine in regimens for drug-susceptible tuberculosis; evaluation of a long-acting injectable formulation of bedaquiline for tuberculosis preventive therapy; and development of nontuberculous mycobacteria infection models for treatment studies.

Categories

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November 2019

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Projects

Understanding the impact of combined TB and...

We are developing models to understand the overlap of TB and HIV in three epidemiologically distinct settings (Canada, India,...

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Comparative Effectiveness/Implementation of...

This cluster-randomized trial in 56 rural primary care clinics compares the effectiveness and implementation of three strategies...

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Statins as adjunctive host-directed therapy...

This study will investigate the role of statins in combination with the first-line regimen for TB in the mouse model. In...

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