Featured Publications
Restocking the tuberculosis drug arsenal
Nuermberger, E.L., Chaisson, R.E. Restocking the tuberculosis drug arsenal. Nat Med 30, 642–643 (2024). https://doi.org/10.1038/s41591-024-02840-y
The magnitude of unfavorable tuberculosis treatment outcomes and their relation with baseline undernutrition and sustained undernutrition among children receiving tuberculosis treatment in central Ethiopia
Burusie A, Enquesilassie F, Salazar-Austin N, Addissie A. The magnitude of unfavorable tuberculosis treatment outcomes and their relation with baseline undernutrition and sustained undernutrition among ...
US Guidelines Fall Short on Short-Course Tuberculosis-Preventive Therapy
Krishnan S, Chaisson RE. US Guidelines Fall Short on Short-Course Tuberculosis-Preventive Therapy. Clin Infect Dis. 2024;78(3):514-517. doi:10.1093/cid/ciad659
Adverse Pregnancy Outcomes Among Women with Human Immunodeficiency Virus Taking Isoniazid Preventive Therapy During the First Trimester
Gupta A, Hughes MD, Cruz JL, et al. Adverse Pregnancy Outcomes Among Women with Human Immunodeficiency Virus Taking Isoniazid Preventive Therapy During the First Trimester. Clin ...
What is next for BCG revaccination to prevent tuberculosis?
White RG, Fiore-Gartland AJ, Hanekom WA, et al. What is next for BCG revaccination to prevent tuberculosis?. Lancet Respir Med. 2024;12(3):e7-e8. doi:10.1016/S2213-2600(24)00009-2
Factors associated with non-completion of TB preventive treatment in Brazil
Cola JP, Nascimento do Prado T, Alves KBA, et al. Factors associated with non-completion of TB preventive treatment in Brazil. Int J Tuberc Lung Dis. 2023;27(3):215-220. ...
Travel distance to rifampicin-resistant tuberculosis treatment and its impact on loss to follow-up: the importance of continued RR-TB treatment decentralization in South Africa
McNabb KC, Bergman AJ, Patil A, et al. Travel distance to rifampicin-resistant tuberculosis treatment and its impact on loss to follow-up: the importance of continued ...
Comparison of 3 optimized delivery strategies for completion of isoniazid-rifapentine (3HP) for tuberculosis prevention among people living with HIV in Uganda: A single-center randomized trial
Semitala FC, Kadota JL, Musinguzi A, et al. Comparison of 3 optimized delivery strategies for completion of isoniazid-rifapentine (3HP) for tuberculosis prevention among people living ...
Active case-finding of tuberculosis compared with symptom-driven standard of care: a modelling analysis
Malhotra A, Ryckman TS, Johnson K, et al. Active case-finding of tuberculosis compared with symptom-driven standard of care: a modelling analysis. Int J Epidemiol. 2024;53(2):dyae019. doi:10.1093/ije/dyae019
Decline in prevalence of tuberculosis following an intensive case finding campaign and the COVID-19 pandemic in an urban Ugandan community
Kendall EA, Kitonsa PJ, Nalutaaya A, Robsky KO, Erisa KC, Mukiibi J, Cattamanchi A, Kato-Maeda M, Katamba A, Dowdy D. Decline in prevalence of tuberculosis ...
Exploring HIV disease indicators at MDR-TB treatment initiation in South Africa
Geiger K, Patil A, Bergman A, Budhathoki C, Heidari O, Lowensen K, Mthimkhulu N, McNabb KC, Mmed NN, Ngozo J, Reynolds N, Farley JE. Exploring ...
The Impact of Preventive Treatment for Multidrug- and Rifampin-Resistant Tuberculosis Exceeds Trial-Based Estimates
Kasaie P, Pennington J, Gupta A, Dowdy DW, Kendall EA. The Impact of Preventive Treatment for Multidrug- and Rifampin-Resistant Tuberculosis Exceeds Trial-Based Estimates. Clin Infect Dis. ...
Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP
Rohilla A, Singh AK, Koleske B, Srikrishna G, Bishai WR. Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP. Microbiol Spectr. ...
Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis
Tucker EW, Ruiz-Bedoya CA, Mota F, Erice C, Kim J, de Jesus P, Jahdav R, Bahr M, Flavahan K, Chen X, Peloquin CA, Freundlich JS, ...
Health care providers acceptance of default prescribing of TB preventive treatment for people living with HIV in Malawi: a qualitative study
De Groot LM, Shearer K, Sambani C, Kaonga E, Nyirenda R, Mbendera K, Golub JE, Hoffmann CJ, Mulder C. Health care providers acceptance of default ...
Early Microbiologic Markers of Pulmonary Tuberculosis Treatment Outcomes
Paradkar MS, Pradhan NN, Balaji S, Gaikwad SN, Chavan A, Dharmashale SN, Sahasrabudhe T, Lokhande R, Deshmukh SA, Barthwal M, Atre S, Raskar SS, Sawant ...
Reducing HIV-associated post-hospital mortality through home-based care in South Africa: a randomized controlled trial
Hoffmann CJ, Shearer K, Kekana B, Kerrigan D, Moloantoa T, Golub JE, Variava E, Martinson NA. Reducing HIV-associated post-hospital mortality through home-based care in South ...
Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis
Parveen, S., Shen, J., Lun, S. et al. Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis. Nat Commun 14, 7427 (2023). https://doi.org/10.1038/s41467-023-43304-0
Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis
Almeida D, Li S-Y, Lee J, Hafkin B, Mdluli K, Fotouhi N, Nuermberger EL. Contezolid can replace linezolid in a novel combination with bedaquiline and ...
Timing of maternal isoniazid preventive therapy on tuberculosis infection among infants exposed to HIV in low-income and middle-income settings: a secondary analysis of the TB APPRISE trial
Gupta A, Singh P, Aaron L, et al. Timing of maternal isoniazid preventive therapy on tuberculosis infection among infants exposed to HIV in low-income and ...
The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions
Koleske BN, Jacobs WR Jr, Bishai WR. The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions. J Clin Invest. 2023;133(19):e173156. Published 2023 Oct 2. ...
HIV/Tuberculosis Coinfection in Pregnancy and the Postpartum Period
Yilma A, Bailey H, Karakousis PC, Karanika S. HIV/Tuberculosis Coinfection in Pregnancy and the Postpartum Period. J Clin Med. 2023;12(19):6302. Published 2023 Sep 29. doi:10.3390/jcm12196302
Prevalence and incidence of tuberculosis infection among healthcare workers in chest diseases hospitals, Bangladesh: Putting infection control into context
Islam MS, Gurley ES, Banu S, et al. Prevalence and incidence of tuberculosis infection among healthcare workers in chest diseases hospitals, Bangladesh: Putting infection control ...
1-Year Incidence of Tuberculosis Infection and Disease Among Household Contacts of Rifampin- and Multidrug-Resistant Tuberculosis
Krishnan S, Wu X, Kim S, et al. 1-Year Incidence of Tuberculosis Infection and Disease Among Household Contacts of Rifampin- and Multidrug-Resistant Tuberculosis. Clin Infect Dis. ...
Sex and Gender Differences in Tuberculosis Pathogenesis and Treatment Outcomes
Dabitao D, Bishai WR. Sex and Gender Differences in Tuberculosis Pathogenesis and Treatment Outcomes. Curr Top Microbiol Immunol. 2023;441:139-183. doi: 10.1007/978-3-031-35139-6_6. PMID: 37695428.
Functional Whole Genome Screen of Nutrient-Starved Mycobacterium tuberculosis Identifies Genes Involved in Rifampin Tolerance
Matern WM, Harris HT, Danchik C, et al. Functional Whole Genome Screen of Nutrient-Starved Mycobacterium tuberculosis Identifies Genes Involved in Rifampin Tolerance. Microorganisms. 2023;11(9):2269. Published 2023 Sep 9. ...
Glycated Hemoglobin Trajectories and Their Association With Treatment Outcomes Among Patients With Pulmonary TB in India: A Prospective Cohort Study
Pardeshi G, Mave V, Gaikwad S, Kadam D, Barthwal M, Gupte N, Atre S, Deshmukh S, Golub JE, Gupte A. Glycated Hemoglobin Trajectories and Their ...
Perceived stigma among people with TB and household contacts
Machavariani E, Nonyane BAS, Lebina L, Mmolawa L, West NS, Dowdy DW, Martinson N, Ahmad B, Hanrahan CF. Perceived stigma among people with TB and ...
Determining cost and placement decisions for moderate complexity NAATs for tuberculosis drug susceptibility testing
Malhotra A, Thompson R, De Vos M, David A, Schumacher S, Sohn H. Determining cost and placement decisions for moderate complexity NAATs for tuberculosis drug ...
Timing of maternal isoniazid preventive therapy on tuberculosis infection among infants exposed to HIV in low-income and middle-income settings: a secondary analysis of the TB APPRISE trial
Gupta A, Singh P, Aaron L, Montepiedra G, Chipato T, Stranix-Chibanda L, Chanaiwa V, Vhembo T, Mutambanengwe M, Masheto G, Raesi M, Bradford S, Golner ...
Modeling the impact of universal tuberculosis molecular testing and timing of tuberculosis preventive treatment during antiretroviral therapy initiation in South Africa
Balasubramanian R, Shearer K, Mudzengi D, Hippner P, Golub JE, Chihota V, Hoffmann CJ, Kendall EA. Modeling the impact of universal tuberculosis molecular testing and ...
Undiagnosed Pulmonary Tuberculosis (TB) and Coronavirus Disease 2019 (COVID-19) in Adults Dying at Home in a High-TB-Burden Setting, Before and During Pandemic COVID-19: An Autopsy Study
Sabet N, Omar T, Milovanovic M, Magajane T, Mosala M, Moloantoa T, Kato-Kalule N, Semedo LV, Swanepoel F, Wallis C, Abraham P, Lebina L, Variava ...
Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection
Jalbert E, Liu C, Mave V, Lang N, Kagal A, Valvi C, Paradkar M, Gupte N, Lokhande R, Bharadwaj R, Kulkarni V, Gupta A, Weinberg ...
Translational predictions of phase 2a first-in-patient efficacy studies for antituberculosis drugs
Ernest JP, Ni Goh JJ, Strydom N, Wang Q, van Wijk RC, Zhang N, Deitchman A, Nuermberger E, Savic RM. Translational predictions of phase 2a ...
Pragmatic cluster-randomized trial of home-based preventive treatment for TB in Ethiopia and South Africa (CHIP-TB)
Malhotra A, Nonyane BAS, Shirey E, Mulder C, Hippner P, Mulatu F, Ratshinanga A, Mitiku P, Cohn S, Conradie G, Chihota V, Chaisson RE, Churchyard ...
Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy
Chang YS, Li SY, Pertinez H, Betoudji F, Lee J, Rannard SP, Owen A, Nuermberger EL, Ammerman NC.
Structure-directed identification of pyridine-2-methylamine derivatives as MmpL3 inhibitors for use as antitubercular agents
Wen Y, Lun S, Jiao Y, Zhang W, Liu T, Yang F, Tang J, Bishai WR, Yu LF.
Effect of the relationship between anaemia and systemic inflammation on the risk of incident tuberculosis and death in people with advanced HIV: a sub-analysis of the REMEMBER trial
Araújo-Pereira M, Krishnan S, Salgame P, Manabe YC, Hosseinipour MC, Bisson G, Severe DP, Rouzier V, Leong S, Mave V, Sawe FK, Siika AM, Kanyama ...
Understanding patient-level costs of weekly isoniazid-rifapentine (3HP) among people living with HIV in Uganda
Sung J, Musinguzi A, Kadota JL, Baik Y, Nabunje J, Welishe F, Bishop O, Berger CA, Katahoire A, Nakitende A, Nakimuli J, Akello L, Kasidi ...
Higher yield using an event-based vs. door-to-door approach for active case-finding for TB
Malhotra A, Mukiibi J, Kitonsa PJ, Nalutaaya A, Kamoga CE, Robsky KO, Isooba D, Nantale M, Nakasolya O, Kayondo F, Mukiibi M, Kiyonga R, Dowdy ...
Viral suppression among adults with HIV receiving routine dolutegravir-based antiretroviral therapy and 3 months weekly isoniazid-rifapentine
Chaisson LH, Semitala FC, Nangobi F, Steinmetz S, Marquez C, Armstrong DT, Opira B, Kamya MR, Phillips PPJ, Dowdy DW, Yoon C.
QuantiFERON Supernatant-Based Host Biomarkers Predicting Progression to Active Tuberculosis Disease among Household Contacts of Tuberculosis Patients
Daniel EA, Thiruvengadam K, Rajamanickam A, Chandrasekaran P, Pattabiraman S, Bhanu B, Sivaprakasam A, Paradkar M, Kulkarni V, Karyakarte R, Shivakumar SVBY, Mave V, Gupta ...
Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses
Adeoye B, Nakiyingi L, Moreau Y, Nankya E, Olson AJ, Zhang M, Jacobson KR, Gupta A, Manabe YC, Hosseinipour MC, Kumwenda J, Sagar M.
A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction
Queiroz ATL, Vinhaes CL, Fukutani ER, Gupte AN, Kumar NP, Fukutani KF, Arriaga MB, Sterling TR, Babu S, Gaikwad S, Karyakarte R, Mave V, Paradhkar ...
Editorial: Broadening our understanding of the impact of infections on the developing central nervous system – from basic to clinical sciences
Travassos MA, Rohlwink UK, Tucker EW.
Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice
Krug S, Prasad P, Xiao S, Lun S, Ruiz-Bedoya CA, Klunk M, Ordonez AA, Jain SK, Srikrishna G, Kramnik I, Bishai WR.
Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model
Li SY, Converse PJ, Betoudji F, Lee J, Mdluli K, Upton A, Fotouhi N, Nuermberger EL.
Do chest x-ray-positive, sputum-negative individuals warrant more attention during tuberculosis screening?
Emily A Kendall, Emily B Wong
Household- Versus Incentive-Based Contact Investigation for Tuberculosis in Rural South Africa: A Cluster-Randomized Trial
Hanrahan CF, Nonyane BAS, Lebina L, Mmolawa L, Siwelana T, West NS, Albaugh N, Martinson N, Dowdy DW.
Number Needed to Screen for Tuberculosis Disease Among Children: A Systematic Review
Robsky KO, Chaisson LH, Naufal F, Delgado-Barroso P, Alvarez-Manzo HS, Golub JE, Shapiro AE, Salazar-Austin N.
Mutations in Rv0678 Reduce Susceptibility of Mycobacterium tuberculosis to the DprE1 Inhibitor TBA-7371
Almeida DV, Converse PJ, Nuermberger EL.
An analytic feasibility study of the BD MAX™ MDR-TB assay for testing of non-sputum specimens for detection of the Mycobacterium tuberculosis complex (MTBC) and isoniazid (INH) and rifampin (RIF) resistance
Armstrong D, Fisher S, Totten M, Parrish N.
Differentially culturable tubercle bacteria as a measure of tuberculosis treatment response
Peters JS, McIvor A, Papadopoulos AO, Masangana T, Gordhan BG, Waja Z, Otwombe K, Letutu M, Kamariza M, Sterling TR, Bertozzi CR, Martinson NA, Kana ...
Pharmacokinetic analysis of linezolid for multidrug resistant tuberculosis at a tertiary care centre in Mumbai, India
Resendiz-Galvan JE, Arora PR, Abdelwahab MT, Udwadia ZF, Rodrigues C, Gupta A, Denti P, Ashavaid TF, Tornheim JA. Pharmacokinetic analysis of linezolid for multidrug resistant ...
Tuberculosis, Wildfires, and Case-crossover Studies: An Epidemiological Trifecta?
Checkley W. Tuberculosis, Wildfires, and Case-crossover Studies: An Epidemiological Trifecta? Am J Respir Crit Care Med. 2023 Feb 1;207(3):242-243. doi: 10.1164/rccm.202210-1936ED. PMID: 36315435; PMCID: PMC9896637.
Multicomponent strategy with decentralised molecular testing for tuberculosis in Uganda: a cost and cost-effectiveness analysis
Thompson RR, Nalugwa T, Oyuku D, Tucker A, Nantale M, Nakaweesa A, Musinguzi J, Reza TF, Zimmer AJ, Ferguson O, Turyahabwe S, Joloba M, Cattamanchi ...
Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies
Mota F, Ruiz-Bedoya CA, Tucker EW, Holt DP, De Jesus P, Lodge MA, Erice C, Chen X, Bahr M, Flavahan K, Kim J, Brosnan MK, ...
Characterising cause of death among people treated for drug-susceptible TB in India
Cox SR, Padmapriyadarsini C, Mave V, Seth B, Thiruvengadam K, Gaikwad S, Sahasrabudhe TR, Sane M, Tornheim JA, Shrinivasa BM, Lokhande R, Barthwal MS, Shivakumar ...
Transcriptional Analysis for Tuberculosis in Pregnant Women From the PRegnancy Associated Changes In Tuberculosis Immunology (PRACHITi) Study
Mathad JS, Queiroz ATL, Bhosale R, Alexander M, Naik S, Kulkarni V, Andrade BB, Gupta A. Transcriptional Analysis for Tuberculosis in Pregnant Women From the ...
Infectious and clinical tuberculosis trajectories: Bayesian modeling with case finding implications
Theresa S Ryckman, David W Dowdy , Emily A Kendall
Disadvantage and the Experience of Treatment for Multidrug-Resistant Tuberculosis (MDR-TB)
SSM Qual Res Health. 2022 Dec;2:100042. Taylor HA, Dowdy DW, Searle AR, Stennett AL, Dukhanin V, Zwerling AA, Merritt MW.
Cost and Cost-Effectiveness of a Digital Adherence Technology for Tuberculosis Treatment Support in Uganda
Value Health. 2022 Jun;25(6):924-930. Thompson RR, Kityamuwesi A, Kuan A, Oyuku D, Tucker A, Ferguson O, Kunihira Tinka L, Crowder R, Turyahabwe S, Cattamanchi A, ...
Ending tuberculosis in a post-COVID-19 world: a person-centred, equity-oriented approach.
Lancet Infect Dis. 2022 Aug 10:S1473-3099(22)00500-X. doi: 10.1016/S1473-3099(22)00500-X. Epub ahead of print. Ryckman T, Robsky K, Cilloni L, Zawedde-Muyanja S, Ananthakrishnan R, Kendall EA, Shrestha ...
Comparative assessment of the cost-effectiveness of Tuberculosis (TB) active case-finding interventions: A systematic analysis of TB REACH wave 5 projects
PLoS One. 2022 Sep 26;17(9):e0270816. Gomes I, Dong C, Vandewalle P, Khan A, Creswell J, Dowdy D, Sohn H.
Quantifying Mycobacterium tuberculosis transmission dynamics across global settings: a systematic analysis
Am J Epidemiol. 2022 Oct 13:kwac181. doi: 10.1093/aje/kwac181. Epub ahead of print. Smith J, Cohen T, Dowdy D, Shrestha S, Gandhi NR, Hill AN.
Analyzing Pragmatic Trials to Inform Cost-Effectiveness Analyses
Value Health. 2022 Oct 29:S1098-3015(22)04688-5. Dowdy DW, Thompson RR, Kityamuwesi A, Crowder R, Cattamanchi A, Katamba A, Sohn H.
Tuberculosis treatment adherence in the era of COVID-19.”
BMC Infect Dis. 2022 Oct 26;22(1):800. doi: 10.1186/s12879-022-07787-4. PMID: 36289485; PMCID: PMC9607764. Lippincott CK, Perry A, Munk E, Maltas G, Shah M.
Tuberculosis Epidemiologic Studies Consortium. Evaluation of the Latent Tuberculosis Care Cascade Among Public Health Clinics in the United States
Clin Infect Dis. 2022 Nov 14;75(10):1792-1799. doi: 10.1093/cid/ciac248. PMID: 35363249. Holzman SB, Perry A, Saleeb P, Pyan A, Keh C, Salcedo K, Narita M, Ahmed ...
Diagnostic biomarkers for active tuberculosis: progress and challenges
EMBO Mol Med. 2022 Oct 31;e14088. doi: 10.15252/emmm.202114088 Betânia M F Nogueira # 1 2 3, Sonya Krishnan # 4, Beatriz Barreto-Duarte 3 5 6 ...
An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis
Front Immunol. 2022 Sep 16;13:972266. doi: 10.3389/fimmu.2022.972266. eCollection 2022. Styliani Karanika 1 2, James T Gordy 3, Pranita Neupane 1 2, Theodoros Karantanos 4, Jennie ...