William R. Bishai, MD, PhD
Co-Director, Center for Tuberculosis Research
Professor, Medicine,Pathology, and Molecular Microbiology Immunology
Area of Research
Bacterial gene regulation, pathogenesis, tuberculosis, latent infections, sigma factors.
Specific Research Interests
Transcription factors regulate bacterial adaptive response for switching between rapid growth leading to overt disease and stationary phase survival during which the host is colonized and at risk for disease. We study the role of stationary phase-specific transcription factors in diseases caused by Mycobacterium tuberculosis and Staphylococcus aureus. Latent tuberculosis is a colonization state which affects one-third of the world’s population and carries a significant risk for active TB. M. tuberculosis possesses 12 alternate RNA polymerase sigma factors several of which govern virulence and persistence in animal models and survival in vitro under stationary phase and stress conditions. We are using molecular genetic strategies including microarray analysis with recombinant bacteria to characterize the roles of these transcription factors in diseases caused by M. tuberculosis. Testing of virulence and persistence is performed locally using either the mouse or rabbit models of tuberculosis.
Additionally, clinical research on TB has been an active interest in the laboratory, and we have ongoing collaborative projects with other members of the Center for Tuberculosis Research on experimental therapeutics and diagnostics, both in Baltimore City and in several foreign settings.
Staff & Students
- Shichun Lun (firstname.lastname@example.org)
- Shashank Gupta (email@example.com)
- Bappaditya Dey firstname.lastname@example.org
- Ruchi Jain Dey email@example.com
- Cynthia Korin Bullen (firstname.lastname@example.org)
- Bintou Ahmadou Ahidjo email@example.com