William R. Bishai, MD, PhD

Co-Director

Titles:

Co-Director, Center for Tuberculosis Research

Professor, Medicine,Pathology, and Molecular Microbiology Immunology

SciVal:

SciVal Link

Area of Research

Bacterial gene regulation, pathogenesis, tuberculosis, latent infections, sigma factors.

Specific Research Interests

Transcription factors regulate bacterial adaptive response for switching between rapid growth leading to overt disease and stationary phase survival during which the host is colonized and at risk for disease. We study the role of stationary phase-specific transcription factors in diseases caused by Mycobacterium tuberculosis and Staphylococcus aureus. Latent tuberculosis is a colonization state which affects one-third of the world’s population and carries a significant risk for active TB. M. tuberculosis possesses 12 alternate RNA polymerase sigma factors several of which govern virulence and persistence in animal models and survival in vitro under stationary phase and stress conditions. We are using molecular genetic strategies including microarray analysis with recombinant bacteria to characterize the roles of these transcription factors in diseases caused by M. tuberculosis. Testing of virulence and persistence is performed locally using either the mouse or rabbit models of tuberculosis.

Additionally, clinical research on TB has been an active interest in the laboratory, and we have ongoing collaborative projects with other members of the Center for Tuberculosis Research on experimental therapeutics and diagnostics, both in Baltimore City and in several foreign settings.

Staff & Students

Research Associate:

Post docs

PhD students

Categories

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Projects

Immunotherapy Targeting MTB Persisters in the...

The goal of this research program is to determine whether enhanced immunity to critical components of the Mtb stringent response...

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Comparative Effectiveness/Implementation of...

This cluster-randomized trial in 56 rural primary care clinics compares the effectiveness and implementation of three strategies...

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A randomized trial of preventive therapy for...

We are evaluating the efficacy and cost-effectiveness of levofloxacin preventive therapy for pediatric contacts of MDR TB...

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A smoking cessation trial in HIV/AIDS...

A tobacco prevalence survey and smoking cessation trial among HIV infected patients in South Africa.

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Understanding and Improving the Effectiveness...

The goal of this project is to construct a mathematical model of the laboratory network for diagnosis of infectious diseases in...

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