Publications
-
Poor Obstetric and Infant Outcomes in HIV-Infected Pregnant Women...
Published: 01/03/2019
BACKGROUND:
Before the wide availability of antiretroviral therapy (ART), tuberculosis and human immunodeficiency virus (HIV) disease among pregnant women resulted in poor maternal and neonatal outcomes, including high...
-
Unprecedented in Vitro Antitubercular Activitiy of Manganese(II)...
Published: 11/30/2018
Mycobacterium tuberculosis is the etiologic agent of tuberculosis. The demand for new chemotherapeutics with unique mechanisms of action to treat (multi)resistant strains is an urgent need. The objective of this work was to...
-
Gene enrichment analysis reveals major regulators of...
Published: 11/30/2018
The development of antibiotic tolerance is believed to be a major factor in the lengthy duration of current tuberculosis therapies. In the current study, we have modeled antibiotic tolerance in vitro by...
-
Altered Mycobacterium tuberculosis cell wall metabolism and...
Published: 11/30/2018
Background: Mycobacterium tuberculosis (Mtb) rpoB mutations are associated with global metabolic remodeling. However, the net effects of rpoB mutations on Mtb physiology, metabolism and function are...
-
Intranasal immunization with DnaK protein induces protective...
Published: 11/30/2018
Mycobacterium tuberculosis (Mtb) remains a global health challenge due to the limited efficacy of the Mtb vaccine in current use, Bacillus Calmette-Guérin (BCG). To date, there is no available vaccine for...
-
Metformin use reverses the increased mortality associated with...
Published: 11/30/2018
Background
The global type 2 diabetes mellitus (DM) epidemic threatens progress made in reducing tuberculosis (TB)–related mortality worldwide. Previous clinical studies have not fully evaluated potential confounding...
-
Development of a novel lead that targets M. tuberculosis...
Published: 11/30/2018
Widespread resistance to first-line TB drugs is a major problem that will likely only be resolved through the development of new drugs with novel mechanisms of action. We have used structure-guided methods to develop a lead...
-
Metformin adjunctive therapy does not improve the sterilizing...
Published: 11/30/2018
Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of tuberculosis (TB). In this study, we sought to investigate the bactericidal and...
-
In vitro and in vivo fitness costs associated with Mycobacterium...
Published: 11/30/2018
Aim:
There is controversy regarding the potential fitness costs of rifampicin (RIF) resistance-conferring mutations in the Mycobacterium tuberculosis (Mtb) rpoB gene. We characterized the pathogenicity...
-
The stringent response factors PPX1 and PPK2 play an important...
Published: 11/30/2018
Mycobacterium tuberculosis remains a global health threat largely due to the lengthy duration of curative antibiotic treatment, contributing to medical nonadherence and the emergence of drug resistance. This prolonged therapy is...
- 1 2 3 > Last ›
