Publications
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Bedaquiline. In Kucers’ the Use of Antibiotics: A Clinical...
Published: 01/31/2019
Bedaquiline (previously R207910, then TMC207) is a firstin- class diarylquinolone antibiotic that was initially approved for the treatment of multidrug-resistant tuberculosis (MDR-TB), tuberculosis (TB) resistant to isoniazid and...
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Tuberculosis Associated with HIV Infection
Published: 01/31/2019
Tuberculosis (TB) has recently surpassed HIV as the primary infectious disease killer worldwide, but the two diseases continue to display lethal synergy. The burden of TB is disproportionately borne by people living...
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Drug-resistant tuberculosis in 2017: At a crossroads
Published: 01/31/2019
In this issue of The Lancet Respiratory Medicine, Dheda and colleagues present one of the most comprehensive pictures to date of the global epidemic of drug-resistant tuberculosis (DR TB).1 This comes at a time of...
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Pyrosequencing to resolve discrepant Xpert MTB/RIF and...
Published: 01/31/2019
Delayed diagnosis of drug resistance has been a major obstacle to proper management and control of drug-resistant tuberculosis (TB). Expanded access to rapid molecular diagnostics such as Xpert MTB/RIF has been...
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Of testing and treatment: implications of implementing new...
Published: 01/31/2019
A novel, shorter-course regimen for treating multidrug-resistant (MDR) tuberculosis was recently recommended by the World Health Organization. However, the most appropriate use of drug...
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Challenges of TB and HIV co-treatment: updates and insights
Published: 01/31/2019
PURPOSE OF REVIEW:
In the past few years, tuberculosis (TB) has overtaken HIV as the infectious disease with the highest global mortality. Successful management of this syndemic will require improved diagnostic...
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The Global Landscape of Tuberculosis Therapeutics
Published: 01/31/2019
Tuberculosis (TB) is one of the oldest infections afflicting humans yet remains the number one infectious disease killer worldwide. Despite decades of experience treating this disease, TB regimens require months of multidrug...
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Multiplex PCR to detect pAmpC β-lactamases among...
Published: 01/31/2019
Drug-resistance due to AmpC β-lactamases represents a growing problem worldwide. In this study, a previously collected sample of 108 cefoxitin-resistant clinical isolates was assessed for AmpC β-lactamase production...
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Few eligible for the newly recommended short course MDR-TB...
Published: 01/28/2019
Background
India has the world’s highest tuberculosis burden, and Mumbai is particularly affected by multidrug resistant tuberculosis (MDR-TB). WHO recommends short, intensive treatment (“Short Course”)...
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Unprecedented in Vitro Antitubercular Activitiy of Manganese(II)...
Published: 11/30/2018
Mycobacterium tuberculosis is the etiologic agent of tuberculosis. The demand for new chemotherapeutics with unique mechanisms of action to treat (multi)resistant strains is an urgent need. The objective of this work was to...
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