Mission

The Mission of the Johns Hopkins Center for Tuberculosis Research (CTR) is to contribute to global tuberculosis control through a range of research and training initiatives in epidemiology, diagnostics, drug development, clinical trials, pathogenesis and basic biology. The CTR, founded in 1998, is comprised of a multi-disciplinary team of scientists working to combat Mycobacterium tuberculosis, a pathogen that causes 1.5 to 2 million deaths every year. Our faculty is drawn from the Schools of Medicine, Bloomberg School of Public Health and Nursing, with a research portfolio that is broad and interdisciplinary. Our major strengths are molecular biology, epidemiology, clinical trials, drug development and mathematical modeling; additional areas of emphasis include animal models, pathogenesis, vaccine development, behavioral research, immunology, and diagnostics.

While research is a primary focus, developing the next cadre of scientists who will contribute to future control efforts is also a major goal. Students from medicine, public health, and nursing have found that the range of topics and locations offer excellent training opportunities. With the slogan, “From bench to bedside and beyond,” the CTR covers everything from genetic epidemiology of TB to population-level studies that have played a major role in forming global policies for TB control.

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Projects

Understanding the role of repeat testing and...

We have developed a Markov model of serial IGRA testing to help improve testing algorithms with TST vs. IGRA in low-risk...

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Modeling the impact of novel TB drug regimens...

We are constructing mathematical models of TB epidemics in Southeast Asia, India, and Vietnam to explore the potential...

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Enhancing models of HIV,viral hepatitis,...

The goal of this five-year project is to assist the United States Centers for Disease Control and Prevention in their approach...

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Options for Patient-Centered Delivery of...

This individually randomized trial is evaluating the relative effectiveness of self-administered therapy, directly observed...

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The role of cell wall lipids in pathogenesis...

This study will use a combination of transcriptional, lipidomic, genetic, and imaging techniques to investigate whether...

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